http://www.pathway2curis.com/cu-907-inhibitor-hdac-and-pi3k-mtor-f18.html CUDC-907 is an orally bioavailable, multi-targeted small molecule that is designed to inhibit HDAC and PI3K, the combination of which Curis scientists believe have synergistic interaction against cancer cells. In vitro mechanism of action studies demonstrate that CUDC-907 is able to inhibit Class I PI3K and upregulate molecules involved in cancer cell death. CUDC-907 has also demonstrated the ability to suppress multiple nodes of other survival pathways as a result of the epigenetic modification resulting from the inhibition of its non-kinase HDAC target. By contrast, single-target PI3K inhibitors only target the primary PI3K survival pathway and reportedly have only limited effects on tumors with disregulation of other signaling pathways. <b>Statistics</b> : 1 Topics || 1 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> Tue, 11 Jan 2011 01:45:46 GMT http://www.pathway2curis.com/gym_sitemaps/images/rss_forum_big.gif http://www.pathway2curis.com/cu-907-inhibitor-hdac-and-pi3k-mtor-f18.html http://blogs.law.harvard.edu/tech/rss Google Yahoo MSN Sitemaps and RSS 2.0.0 - © 2006, 2007, 2008 www.phpBB-SEO.com 6 CUDC-907 is an orally bioavailable, multi-targeted small molecule that is designed to inhibit HDAC and PI3K, the combination of which Curis scientists believe have synergistic interaction against cancer cells. In vitro mechanism of action studies demonstrate that CUDC-907 is able to inhibit Class I PI3K and upregulate molecules involved in cancer cell death. CUDC-907 has also demonstrated the ability to suppress multiple nodes of other survival pathways as a result of the epigenetic modification resulting from the inhibition of its non-kinase HDAC target. By contrast, single-target PI3K inhibitors only target the primary PI3K survival pathway and reportedly have only limited effects on tumors with disregulation of other signaling pathways. <b>Statistics</b> : 1 Topics || 1 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span>RSS 2.0 feed link http://www.pathway2curis.com/cu-907-inhibitor-hdac-and-pi3k-mtor-f18/news/forum.xml gym_sitemaps http://www.pathway2curis.com/about-cudc-907-t26.html Tue, 11 Jan 2011 01:45:46 GMT <h5><a href="http://www.pathway2curis.com/cu-907-inhibitor-hdac-and-pi3k-mtor-f18.html" title="CU-907 (Inhibitor HDAC and PI3K/mTOR)">CU-907 (Inhibitor HDAC and PI3K/mTOR)</a></h5> <b>Statistics</b> : 1 Post || 485 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog CU-907 (Inhibitor HDAC and PI3K/mTOR) - News http://www.pathway2curis.com/about-cudc-907-t26.html