Curis new Multi target single agent molecules

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Curis new Multi target single agent molecules
hedgehog
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Joined: 19 Jan 2006
Posts: 820
Location: Bay Area
Post Posted: Thu Oct 12, 2006 9:46 pm Reply with quote
Rationale for Multi-Target Inhibitors
The case for multi-target drugs: Oncology

  • Heterogeneity of cells within tumors
  • Redundancy of proliferative and survival pathways
  • Potential synergies could lead to superior efficacy,
    which is expected to lead to reduced dosage and
    toxicity
  • Simultaneous inhibition of several cellular targets
    could reduce drug resistance in human
    malignancies











  • Single agent targeting 2 or more validated targets (A+B) by
    combining the active portions of known drugs into single
    enhanced proprietary compound
  • Curis is seeking to combine validated therapies against known
    targets
  • The combination approach could lead to synergistic efficacy with
    reduced toxicity profiles.
  • Curis anticipates filing first IND for proprietary multi-targeting
    drugs 2H 2007 or 1H 2008


www.curis.com

You get multi targets 4 cancer for the price of a single agent. Genius!

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Curis new Multi target single agent molecules
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