A new study, published by Cell Press in the journal Molecular Cell, identifies a pivotal role for the CUL7 E3 ubiquitin ligase in growth control. The research makes an exciting new connection between the regulation of protein degradation and the initiation of cellular senescence.CUL7 E3 is an E3 ubiquitin ligase that plays a critical role in mediating selective degradation of target proteins and, therefore, has a substantial impact on numerous biological processes.

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