I listened to their presentation last night. The only thing that i picked up on that was new was Wyeth is looking into making a stable Hh-protein, that crosses the Blood Brain Barrier for stroke. It sounds like they have already been successful at doing this. If you remember for heart attack patients they were going to use a protein pellet to keep the cells alive and not die. He sort of implied that this protein could be used for Stroke and heart attack patients.

It should also be noted that the Hh-protein turns on the pathway at a different step. It is actually the binds to a protein called patched. Their agonists binded to a protein called SMO, which is further down in the pathway. I guess the idea behind this is the following.
1) In normal cell ptch keeps the Hh pathway off
2) When Hh is present and binds to ptch it allows the pathway to be turned on
3) Now the key to targeting the pathway this way is. When the pathway is turned on PTCH is one of the first proteins that get transcribed. The reason for this is that it causes a negative feedback system because when PTCH gets unregulated it helps to turn the pathway off. So this is much better for tox studies because it is using the pathways normal means of correcting mechanism. Their first way of targeting the pathway for stroke was to target SMO which is not susceptible to this normal corrective mechanism.