All patents have been converted to PDF and uploaded to the server:

Please note that these are only the patents that have been assigned to “curis”. They probably have a lot more under names of people who work there such as Lee Rubin. If any of the links do not match the patent please let me know.

Mediators of hedgehog signaling pathways, compositions and uses related thereto
patent

Hydrophobically-modified hedgehog protein compositions and methods
patent

Active hedgehog protein conjugate
patent

Mediators of hedgehog signaling pathways, compositions and uses related thereto
patent

Human patched genes and proteins, and uses related thereto
patent

Small organic molecule regulators of cell proliferation
patent

Methods of modulating lipid metabolism and storage
patent

Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
patent

Small organic molecule regulators of cell proliferation
patent

Agonists of hedgehog signaling pathways and uses related thereto
patent

Regulators of the hedgehog pathway, compositions and uses related thereto
patent

Neuroprotective methods and reagents
patent

Active hedgehog protein conjugate
patent

Methods and compositions for treating or preventing peripheral neuropathies
patent

Hydrophobically-modified protein compositions and methods
patent

Pancreatic progenitor cells, methods and uses related thereto
patent

Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
patent

Method for enhancing functional recovery following central nervous system ischemia or trauma
patent

Morphogen treatment for chronic renal failure
patent

Methods and compositions for the treatment and prevention of Parkinson's disease
patent

Protein-induced morphogenesis in liver tissue
patent

Morphogen-induced neural cell adhesion
patent

Modulators of morphogen expression and methods of identifying the same
patent

Therapies for chronic renal failure
patent

Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors
patent

Morphogen-induced dendritic growth
patent

Methods and compositions for regulating lymphocyte activity
patent

United States Patent 6,994,990 Lang , et al. February 7, 2006


Active modified hedgehog proteins

Abstract
The present invention provides isolated highly active hedgehog proteins esterified with a fatty acid having from 14 to 20 carbon atoms at the N-terminal domain of the protein. The highly active hh proteins are particularly useful therapeutic agents for treating bone disorders and neurodegenerative diseases. Methods for obtaining the highly active modified hedgehog proteins are also provided.



SUMMARY OF THE INVENTION

The object of the invention is to produce hh proteins (polypeptides) which have a considerably improved activity compared to the known forms. In accordance with the present invention, the highly active hh proteins are particularly useful for inducing or stimulating chondrocytes and osteocytes as well as for treating neurodegenerative diseases. Thus, the highly active hh proteins of the present invention are useful therapeutic agents for treating bone disorders such as, for example, osteoporosis and bone fractures.