Patents Pending

Posted: Fri Jan 27, 2006 8:30 pm

All patents have been converted to PDF and uploaded to the server:

Please note that these are only the patents that have been assigned to “curis”. They probably have a lot more under names of people who work there such as Lee Rubin. If any of the links do not match the patent please let me know.

Cool

Posted: Sun Jan 29, 2006 2:09 pm

Insulin promoter factor, and uses related thereto
pat20020082410.pdf 3.1M

Novel morphogenic protein compositions of matter
pat20030105004.pdf 2.3M

Small organic molecule regulators of cell proliferation
pat20030139457.pdf 7.4M

Morphogen analogs of bone morphogenic proteins
pat20030185792.pdf 5.1M

Mediators of hedgehog signaling pathways, compositions and uses related thereto
pat20040023949.pdf 5.7M

Protein-induced morphogenesis
pat20040102373.pdf 6.2M

Regulators of the hedgehog pathway, compositions and uses related thereto
pat20040127474.pdf 4.3M

Active modified hedgehog proteins
pat20040138130.pdf 1.0M

Method and compositions for treating dopaminergic and gabanergic disorders
pat20040220096.pdf 6.0M

Methods and reagents for treating glucose metabolic disorders
pat20040228846.pdf 3.2M

Neuroprotective methods and reagents
pat20040235739.pdf 3.7M

Mediators of hedgehog signaling pathways, compositions and uses related thereto
pat20050014796.pdf 5.7M

Stem cell-based methods for identifying and characterizing agents
pat20050019801.pdf 5.7M

Mediators of hedgehog signaling pathways, compositions and uses related thereto
pat20050080138.pdf 4.7M

Methods of modulating lipid metabolism and storage
pat20050112125.pdf 4.0M

Hydrophobically-modified protein compositions and methods
pat20050119181.pdf 4.0M

Novel therapies for chronic renal failure
pat20050143304.pdf 1.5M

Active hedgehog protein conjugate
pat20050148510.pdf 1.1M

Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors
pat20050164938.pdf 1.2M

Composition and methods for modulating CNS activity
pat20050203014.pdf 5.3M

Modulators of morphogen expression and methods of identifying the same
pat20050208533.pdf 2.6M

Methods of antagonizing morphogens
pat20050233379.pdf 2.8M

Methods and compositions for regulating lymphocyte activity
pat20050256074.pdf 8.7M

RNA interference modulators of hedgehog signaling and uses thereof
pat20050256076.pdf 10M

Progenitor cells, methods and uses related thereto
pat20050266555.pdf 6.7M

Regulators of the hedgehog pathway, compositions and uses related thereto
pat20060020020.pdf 4.3M

Posted: Fri Feb 03, 2006 1:10 pm

Morphogen-induced dendritic growth

Abstract

Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.

Quote:

BACKGROUND OF THE INVENTION

[0002] The present invention relates to methods for enhancing the survival of neuronal cells in vivo and to methods, compositions and devices for maintaining neural pathways in vivo. More particularly, the invention provides methods for enhancing survival of neuronal cells at risk of dying, including methods for redifferentiating transformed cells of neural origin and methods for maintaining phenotypic expression of differentiated neuronal cells. The invention also provides means for repairing damaged neural pathways, including methods for stimulating axonal growth over extended distances, and methods for alleviating immunologically-related nerve tissue damage. In a particular embodiment, this invention provides a method for stimulating cell adhesion molecule expression in cells, and particularly nerve cell adhesion molecule expression in neurons. The invention further provides means for evaluating nerve tissue stasis and identifying neural dysfunction in a mammal. In other specific embodiments, the invention provides methods and compositions for promoting dendrite outgrowth of neural cells from both the central and peripheral nervous system.

Quote:

DETAILED DESCRIPTION OF THE INVENTION

[0074] It now has been discovered that the proteins described herein are effective agents for enhancing the survival of neurons, particularly neurons at risk of dying, and for maintaining neural pathways in a mammal. As described herein, these proteins ("morphogens") can enhance survival of non-mitotic neurons, stimulate neuronal CAM expression, maintain the phenotypic expression of differentiated neurons, induce the redifferentiation of transformed cells of neural origin, and stimulating axonal growth over breaks in neural processes, particularly large gaps in distal axons. The proteins also can provide a neuroprotective effect to alleviate the tissue destructive effects associated with immunologically-related nerve tissue damage. Finally, the proteins can be used in a method for monitoring the viability of nerve tissue in a mammal.

This is a different patent compared to curis other patents. This deals with modulating a protein call CAM. However, still deals closely with curis expertise that being morphogens and embryonic development.

download patent