Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors

Hedgehog Pathway Cancers Clinical Trials

IPI-926 vs GDC-0449 vs Itraconazole

All of the following compounds work at blocking the activating forms of a Hh signaling protein called "SMO." IP-926 team took a well known inhibitor and made it work better. GDC-0449 said I know I want to inhibit SMO lets make a brand new ...

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Hedgehog Pathway Articles

Nevoid Basal Cell Carcinoma Syndrome LDE225

Very interesting article and is a very different approach compared to GDC-0449

LDE225 (Hedgehog inhibitor)

• Cream Form
• CONS: May not take help Odontogenic keratocyst and Plantar Pits in these patients. Will not prevent new BCCs (Unless they take the cream lotion on a ...

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Hedgehog Pathway Articles

Resolution of Odontogenic Keratocysts of the Jaw in Basal Ce

Abstract
BACKGROUND: Odontogenic keratocysts of the jaw are a central feature of basal cell nevus syndrome (BCNS) and arise from the basal cell layer of the surface epithelium. Although they are benign, they tend to be aggressive, with local invasion ...

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Hedgehog Pathway Articles

Hedgehog AACR 2011

Abstract Number: LB-1
Presentation Title: An investigator-initiated, phase II randomized, double-blind, placebo-controlled trial of GDC-0449 for prevention of BCCs in basal cell nevus syndrome (BCNS) patients
Presentation Time: Sunday, Apr 03, 2011, 10:30 AM -10:50 AM
Location: West Hall D, Orange County Convention Center
Author Block: Jean ...

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Hedgehog Pathway Cancers Clinical Trials

Stanford University - Itraconazole - BCC

Itraconazole, is an already approved drug as an oral antifungal but it has been show by a research team to also inhibit the Hh pathway. It was also shown to inhibit the pathway differently than the current SMO inhibitors in the clinic.

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Hedgehog Pathway Cancers Clinical Trials

Vismodegib basal cell nevus syndrome

NEW ORLEANS - An oral inhibitor of the hedgehog pathway proved dramatically effective for the treatment and prevention of basal cell carcinomas in patients with basal cell nevus syndrome in a phase II study.

Indeed, the randomized double-blind trial was halted early for ethical ...

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CU-907 (Inhibitor HDAC and PI3K/mTOR)

About CUDC-907

CUDC-907 is an orally bioavailable, multi-targeted small molecule that is designed to inhibit HDAC and PI3K, the combination of which Curis scientists believe have synergistic interaction against cancer cells. In vitro mechanism of action studies demonstrate that CUDC-907 is able to inhibit Class I PI3K and upregulate molecules ...

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Hedgehog Pathway Cancers Clinical Trials

Millennium Pharmaceuticals Hedgehog Inhibitor TAK-441

A Study of TAK-441 in Adult Patients With Advanced Nonhematologic Malignancies P1
http://clinicaltrials.gov/ct2/show/NCT01204073
This is the first study in which TAK-441 is administered to humans. The patient population will consist of adults aged 18 or older who have advanced nonhematologic malignancies and for whom standard ...

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CU-906 (Inhibitor HDAC and PI3K/mTOR)

CU-906 Preclinical information

Activation of the PI3K-AKT-mTOR signaling pathway plays a crucial role in cancer
development and progression. Recently, the inhibition of this pathway has been
extensively investigated as a potential cancer therapy. However, primary or
acquired resistance may present a major challenge to the success of inhibitors
targeting this ...

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CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases)

CU-201 Preclinical Data

"Recent Evidence has established Src Family Kindases as a critical component of multipule signaling pathways that regulate proliferation survival, angiogenesis and metastasis..... Synergy between HDAC and Src inhibition has been demonstrated in cancer cell lines. CU-201 is a single small molecule to inhibit HDAC, Src, and BCR-Abl. ...

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