Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors

Hedgehog Pathway Cancers Clinical Trials

Pancreatic Cancer PII w/ GDC-0449, Gemcitabine, Abraxane

The emergence of new small molecules with capacity of blocking the Hedgehog signaling pathway provides a novel therapeutic approach in pancreatic adenocarcinoma treating the primary tumor, stroma, systemic metastases and pancreatic cancer stem cells by hedgehog pathway inhibition. This phase 2 clinical trial ...

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Hedgehog Pathway Clinical Implications

Resistance to hedgehog pathway SMO Inhibitors

Like other cancer drugs there is a growing body of evidence that Cancers can adapt to single mono-therapy of Hedgehog SMO inhibitors

• Mutation in SMO (the protein that the first generation of Hh inhibitors work on)
• Increased amplification of downstream targets in the ...

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CUDC-101 (HDAC/EGFR/Her2 inhibitor)

CUDC-101 Medicinal Chemistry Information

Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer.

http://pubs.acs.org/doi/full/10.1021/jm901453q

By incorporating histone deacetylase (HDAC) inhibitory functionality into the pharmacophore of the epidermal growth factor receptor (EGFR) and human epidermal ...

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Hedgehog Pathway Articles

Feb-2010 Hedgehog Pathway Articles

Human Invasive Prostate Cancer Cells

Altogether, these observations suggest that EGFR and sonic hedgehog cascades may represent the potential therapeutic targets of great clinical interest to eradicate the total prostate cancer cell mass and improve the current docetaxel-based therapies against locally advanced and invasive prostate cancers, ...

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Hedgehog Pathway Cancers Clinical Trials

Notch-Hedge Clinical Trials Developmental Pathway

http://clinicaltrials.gov/ct2/show/NCT01071564

The Notch like the Hedgehog pathway is very important in stem cell maintenance and repair of cells. This is also a Roche Compound.

http://www.cnb.uam.es/~jlpompa/


The second is a blocker of Hh (hedgehog) signaling, GDC-0449, which we are combining ...

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Hedgehog Pathway Diagrams and Animations

Hedgehog Pathway Images and Videos

Genentech:

Genentech Hedgehog Pathway Video

You Tube:

An award-winning short video clip exploring the Sonic Hedgehog Signaling Pathway for an Embryology - CBNS 169 course.
Won the first ever best editing video award for CBNS 169!!! ...

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Hedgehog Pathway Clinical Implications

Adult Cells and the Hedgehog Pathway

The theory of Adult Stem Cells causing some/most cancers goes like this.

There is long-known association between cancer and chronic tissue injury. For example, if you stay out in the sun your are more likely to develop skin cancer. If you smoke you increase ...

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Hedgehog Pathway Cancer and Metastasis

Hedgehog Pathway Cancer and Metastasis

Hedgehog Pathway Cancer and Metastasis

Increase Hh Pathway Activation leads to Increase Snail protein expression and Decreased E-cadherin & Tight Junctions

E-cadherin stretches across the cell membrane and acts as a sort of molecular “glue” that binds neighboring cells together. About 95 percent of human ...

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Hedgehog Pathway Clinical Implications

Hedgehog Pathway Clinical Implications

There are three main focuses of research surrounding the Hh pathway that could become relevant in a clinical application

1) Embryonic Stem cells for regenerative medicine (agonist/antagonist)
2) Agonist (turns pathway on)---which encompasses, degenerative diseases, stroke, hair growth in the adult body
3) Antagonist (turns pathway ...

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Hedgehog Pathway Cancers Clinical Trials

PII Trial Started of Pancreatic Cancer and GDC-0499

http://clinicaltrials.gov/ct2/show/NCT01064622
Gemcitabine Hydrochloride With or Without GDC-0449 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer
Purpose
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor ...

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