Conclusions:
- CU-201 is a potent inhibitor of HDAC, Src and Bcr-Abl
- It exhibits ...
Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors
Novel Anti-Cancer therapies
It is currently Sat May 19, 2012 12:38 pm
News of CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases)
Site map of CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases) » Forum : CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases)
CU-201 is a network-targeted molecule that is designed to simultaneously inhibit HDAC, Abl and Src family kinases, the combination of which Curis scientists believe have synergistic interaction against cancer cells. Src family kinases are critical components of multiple signaling pathways that regulate cancer cell proliferation, survival, angiogenesis and metastasis. Thus, as a network disrupting agent that directly targets multiple nodes of genetic and epigenetic dysregulation, CU-201 is expected to impact processes as diverse as proliferation, survival, metastasis and angiogenesis in cancer. In vitro studies demonstrate that CU-201 is able to potently inhibit class I and class II HDACs, Src and Bcr-Abl. It has been shown to outperform single target agents in proliferation assays of hematologic and solid tumor lines and to inhibit migration and invasion of cancer cell lines in vitro. In vivo, it displays potent anti-tumor activity in a variety of hematologic and solid tumor models, including subcutaneous, metastatic and orthotopic models.CU-201 Preclinical Data
"Recent Evidence has established Src Family Kindases as a critical component of multipule signaling pathways that regulate proliferation survival, angiogenesis and metastasis..... Synergy between HDAC and Src inhibition has been demonstrated in cancer cell lines. CU-201 is a single small molecule to inhibit HDAC, Src, and BCR-Abl. Here we report its activity in hematologic and solid tumor cell lines and in vivo"
Conclusions:
Conclusions:
Read more : CU-201 Preclinical Data | Views : 350 | Replies : 0
Last 10 active topics
Statistics
Total posts 49 • Total topics 32 • Total members 44
Site map
SitemapIndex
RSS Feed