Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors

Very interesting article and is a very different approach compared to GDC-0449

LDE225 (Hedgehog inhibitor)

• Cream Form
• CONS: May not take help Odontogenic keratocyst and Plantar Pits in these patients. Will not prevent new BCCs (Unless they take the cream lotion on a regular basis)
• PROS: Min/No side effects. No hair loss or muscle spasms

GDC-0449 (Hedgehog inhibitor)

• Systemic
• CONS: Higher incidence side effects.
• PROS: Will probably prevent new BCCs for forming. Will ...

Abstract
BACKGROUND: Odontogenic keratocysts of the jaw are a central feature of basal cell nevus syndrome (BCNS) and arise from the basal cell layer of the surface epithelium. Although they are benign, they tend to be aggressive, with local invasion of bony structures, extensive growth, and potential for substantial disfigurement and speech dysfunction. Complete surgical resection is the current standard of care; however, the procedures are often technically challenging and are followed by high recurrence ...

Abstract Number: LB-1
Presentation Title: An investigator-initiated, phase II randomized, double-blind, placebo-controlled trial of GDC-0449 for prevention of BCCs in basal cell nevus syndrome (BCNS) patients
Presentation Time: Sunday, Apr 03, 2011, 10:30 AM -10:50 AM
Location: West Hall D, Orange County Convention Center
Author Block: Jean Y. Tang, Julian M. Mackay-Wiggan, Michelle Aszterbaum, Joselyn Lindgren, Kris Chang, Carol Coppola, Angela Campbell, Anita Chanana, Jackleen Marji, Chris Callahan, Robert Yauch, David R. Bickers, Ervin H. ...

Human Invasive Prostate Cancer Cells

Altogether, these observations suggest that EGFR and sonic hedgehog cascades may represent the potential therapeutic targets of great clinical interest to eradicate the total prostate cancer cell mass and improve the current docetaxel-based therapies against locally advanced and invasive prostate cancers, and thereby prevent metastases and disease relapse.
http://www.ncbi.nlm.nih.gov/pubmed/20179163

origin of basal cell carcinoma

http://www.ncbi.nlm.nih.gov/pubmed/20154679

Increased expression of the hedgehog signaling pathway in pediatric ...