Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors

Hedgehog Pathway Cancer and Metastasis

Increase Hh Pathway Activation leads to Increase Snail protein expression and Decreased E-cadherin & Tight Junctions

E-cadherin stretches across the cell membrane and acts as a sort of molecular “glue” that binds neighboring cells together. About 95 percent of human cancers arise from epithelial cell types that rely on E-cadherin adhesion to maintain their orderly structure. Without this E-cadherin glue, cancer cells are able to metastasize. “Our view is that ...