Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors

Like other cancer drugs there is a growing body of evidence that Cancers can adapt to single mono-therapy of Hedgehog SMO inhibitors

• Mutation in SMO (the protein that the first generation of Hh inhibitors work on)
• Increased amplification of downstream targets in the pathway such as Gli2
• Increased expression and activation of phosphatidylinositol-3-kinase (PI3K)

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma

The Hedgehog (Hh) signaling pathway is inappropriately activated in ...

The theory of Adult Stem Cells causing some/most cancers goes like this.

There is long-known association between cancer and chronic tissue injury. For example, if you stay out in the sun your are more likely to develop skin cancer. If you smoke you increase your risk for lung cancers. Another example is drinking. Continued chemical insult can also cause many cancers or even environmental factors.

How does this relate to ASC?

Every time your tissue ...

There are three main focuses of research surrounding the Hh pathway that could become relevant in a clinical application

1) Embryonic Stem cells for regenerative medicine (agonist/antagonist)
2) Agonist (turns pathway on)---which encompasses, degenerative diseases, stroke, hair growth in the adult body
3) Antagonist (turns pathway off)----Cancer http://www.pathway2curis.com/the-hedgehog-pathway-and-its-cancers-f7.html

I will touch on the basics of each topic and in the science section of this forum you can dig into the details of each one.

1) ...