Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors

http://clinicaltrials.gov/ct2/show/NCT01071564

The Notch like the Hedgehog pathway is very important in stem cell maintenance and repair of cells. This is also a Roche Compound.

http://www.cnb.uam.es/~jlpompa/


The second is a blocker of Hh (hedgehog) signaling, GDC-0449, which we are combining with a blocker of gamma secretase (RO4929097) in a novel study for people with recurrent sarcomas. We are seeking funding to perform this multi-center study, focusing on biopsies ...

Genentech:

Genentech Hedgehog Pathway Video

You Tube:

An award-winning short video clip exploring the Sonic Hedgehog Signaling Pathway for an Embryology - CBNS 169 course.
Won the first ever best editing video award for CBNS 169!!! :)
http://www.youtube.com/watch?v=ZryiyO32q-0

Infinity Pharma

http://www.infi.com/images/MOA-Hedge-Function.swf

The Hedgehog signaling pathway is a target of growing interest in the oncology community. It represents a new way ...

The theory of Adult Stem Cells causing some/most cancers goes like this.

There is long-known association between cancer and chronic tissue injury. For example, if you stay out in the sun your are more likely to develop skin cancer. If you smoke you increase your risk for lung cancers. Another example is drinking. Continued chemical insult can also cause many cancers or even environmental factors.

How does this relate to ASC?

Every time your tissue ...

Hedgehog Pathway Cancer and Metastasis

Increase Hh Pathway Activation leads to Increase Snail protein expression and Decreased E-cadherin & Tight Junctions

E-cadherin stretches across the cell membrane and acts as a sort of molecular “glue” that binds neighboring cells together. About 95 percent of human cancers arise from epithelial cell types that rely on E-cadherin adhesion to maintain their orderly structure. Without this E-cadherin glue, cancer cells are able to metastasize. “Our view is that ...

There are three main focuses of research surrounding the Hh pathway that could become relevant in a clinical application

1) Embryonic Stem cells for regenerative medicine (agonist/antagonist)
2) Agonist (turns pathway on)---which encompasses, degenerative diseases, stroke, hair growth in the adult body
3) Antagonist (turns pathway off)----Cancer http://www.pathway2curis.com/the-hedgehog-pathway-and-its-cancers-f7.html

I will touch on the basics of each topic and in the science section of this forum you can dig into the details of each one.

1) ...

http://clinicaltrials.gov/ct2/show/NCT01064622
Gemcitabine Hydrochloride With or Without GDC-0449 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer
Purpose
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. GDC-0449 may slow the growth of tumor cells. It is not yet known whether giving gemcitabine hydrochloride together with GDC-0449 is ...

Advanced Solid Tumors
http://clinicaltrials.gov/ct2/show/NCT00880308?term=LDE225 PI
This first-in-human dose-escalation study is to characterize the safety, tolerability, pharmacokinetics and pharmacodynamics of LDE225 given orally on a daily dosing schedule in patients with advanced solid tumors.

• Study Start Date: March 2009
• Estimated Primary Completion Date: December 2010

Skin Basal Cell Carcinomas in Gorlin's Syndrome Patients PI / PII
http://clinicaltrials.gov/ct2/show/NCT00961896?term=LDE225
A double-blind, randomized, vehicle-controlled Proof of Concept (PoC) study to evaluate the safety, local tolerability, pharmacokinetics and pharmacodynamics of ...

Advanced and/or Metastatic Solid Tumor Malignancies PI
http://clinicaltrials.gov/ct2/show/NCT00761696?term=IPI-926
A Phase 1 Study of IPI-926 in Patients With Advanced and/or Metastatic Solid Tumor Malignancies

A Study Evaluating IPI-926 in Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer PI/PII
http://clinicaltrials.gov/ct2/show/NCT01130142
Study IPI-926-03 is a Phase 1b/2 clinical trial to evaluate IPI 926 in combination with gemcitabine in patients with previously untreated metastatic pancreatic cancer. Phase 1b is designed as a dose escalation study. Once the maximum ...

First Line Colon Cancer

Completed Enrollment Q2 2009 N=199

Advanced Ovarian Cancer

Completed Enrollment Q4 2009 N=104

Advanced BCC

FPI Q1 2009 N=100

Mutation Driven

• Rhabdomyosarcoma
• Medulloblastoma
• Nevoid Basal Cell Carcinoma Syndrome (NBCCS)
• Basal Cell Carcinoma
• Gorlin Syndrome

Ligand Driven

• Breast Cancer
• Esophageal Cancer
• Gastric Cancer
• Glioblastoma
• Pancreatic Cancer
• Prostate Cancer
• Small-Cell Lung Cancer (SCLC)
• Colon Cancer