Opposing roles for glypicans in Hedgehog signalling

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Opposing roles for glypicans in Hedgehog signalling
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Post Posted: Wed Jul 16, 2008 8:18 am Reply with quote


Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions.

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Source: Nature Cell Biology
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Opposing roles for glypicans in Hedgehog signalling
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