Overlapping Tumor Suppressor Genes Independently Involved I

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Overlapping Tumor Suppressor Genes Independently Involved I
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Post Posted: Wed May 28, 2008 9:58 pm Reply with quote
Mutations in the p14ARF tumor suppressor gene (ARF) may play a role in melanoma, independent of the effect of the p16 gene.ARF and p16 are overlapping genes at a location on chromosome 9 that is frequently mutated in melanomas. Although researchers have previously demonstrated that inactivation of the p16 tumor suppressor gene occurs frequently in melanomas, it has been less clear whether alterations in ARF occur independently of p16 in human melanoma.

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Overlapping Tumor Suppressor Genes Independently Involved I
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