[Research progress of neural stem cells signal transduction pathway]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Apr;22(4):492-5
Authors: Zhang W, Wang Y, Wang X, Lv J
OBJECTIVE: To summarize Notch, basic helix-loop-helix (bHLH) and Wnt gene signal transduction pathways in the process of differentiation and development of neural stem cells. METHODS: The literature on the gene signal transduction pathway in the process of differentiation and development of neural stem cells was searched and then summarized and analyzed. RESULTS: The formation of Nervous System resulted from common actions of multi-signal transduction pathways. There may exist a fixed threshold in the complicated selective system among Notch, bHLH and Wnt gene signal transduction pathways. CONCLUSION: At present, the specific gene signal transduction pathway of multiplication and differentiation of neural stem cells is still unclear.
PMID: 18575456 [PubMed - in process]
Read more...
Source:
PubMed: Wnt
NCBI: db=PubMed; Term=Wnt
