http://www.pathway2curis.com/ Novel Anti-Cancer therapies This channel list is listing the available RSS feeds. Tue, 07 Feb 2012 21:26:13 GMT http://www.pathway2curis.com/gym_sitemaps/images/rss_forum_big.gif http://www.pathway2curis.com/ http://blogs.law.harvard.edu/tech/rss Google Yahoo MSN Sitemaps and RSS 2.0.0 - © 2006, 2007, 2008 www.phpBB-SEO.com 96 Novel Anti-Cancer therapies This channel list is listing the available RSS feeds. RSS 2.0 feed link http://www.pathway2curis.com/rss/news/ gym_sitemaps http://www.pathway2curis.com/ Tue, 07 Feb 2012 21:26:13 GMT Novel Anti-Cancer therapies This channel list is listing the available RSS feeds. Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors - Channel list http://www.pathway2curis.com/ http://www.pathway2curis.com/ Tue, 07 Feb 2012 21:26:13 GMT Latest news from Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors Novel Anti-Cancer therapies Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors - News http://www.pathway2curis.com/ http://www.pathway2curis.com/ Tue, 07 Feb 2012 21:26:13 GMT Novel Anti-Cancer therapies <b>Statistics</b> : Total members <strong>44</strong> || Total topics <strong>32</strong> || Total posts <strong>46</strong> Our newest member <strong>JPZaragoza</strong> Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors http://www.pathway2curis.com/ http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html Fri, 03 Jun 2011 15:32:35 GMT List of Clinical Hedgehog Pathway Cancers <b>Statistics</b> : 13 Topics || 22 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> Hedgehog Pathway Cancers Clinical Trials - Channel list - News http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html http://www.pathway2curis.com/hedgehog-pathway-articles-f15.html Fri, 25 Mar 2011 15:31:38 GMT A list of important clinical related articles <b>Statistics</b> : 4 Topics || 4 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> Hedgehog Pathway Articles - Channel list - News http://www.pathway2curis.com/hedgehog-pathway-articles-f15.html http://www.pathway2curis.com/cu-907-inhibitor-hdac-and-pi3k-mtor-f18.html Tue, 11 Jan 2011 01:45:46 GMT CUDC-907 is an orally bioavailable, multi-targeted small molecule that is designed to inhibit HDAC and PI3K, the combination of which Curis scientists believe have synergistic interaction against cancer cells. In vitro mechanism of action studies demonstrate that CUDC-907 is able to inhibit Class I PI3K and upregulate molecules involved in cancer cell death. CUDC-907 has also demonstrated the ability to suppress multiple nodes of other survival pathways as a result of the epigenetic modification resulting from the inhibition of its non-kinase HDAC target. By contrast, single-target PI3K inhibitors only target the primary PI3K survival pathway and reportedly have only limited effects on tumors with disregulation of other signaling pathways. <b>Statistics</b> : 1 Topics || 1 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> CU-907 (Inhibitor HDAC and PI3K/mTOR) - Channel list - News http://www.pathway2curis.com/cu-907-inhibitor-hdac-and-pi3k-mtor-f18.html http://www.pathway2curis.com/cu-906-inhibitor-hdac-and-pi3k-mtor-f17.html Fri, 10 Dec 2010 01:54:25 GMT CU-906 is a multi-targeted molecule that is designed to inhibit HDAC and PI3K and mTOR kinases, the combination of which Curis scientists believe have synergistic interaction against cancer cells. In vitro mechanism of action studies demonstrated that CU-906 is able to inhibit Class I PI3K and mTOR kinases, suppress multiple nodes of other survival pathways including the RAF-MEK-ERK pathway, and upregulate P21, which is a cyclin-dependent kinase inhibitor that can promote cancer cell death when upregulated. The suppression of non-PI3K-AKT-mTOR survival pathways occurs via epigenetic modification as a result of the inhibition of HDAC, the non-kinase target of CU-906. By contrast, single-target PI3K inhibitors and PI3K/mTor dual inhibitors that only target the primary PI3K and/or mTOR kinase survival pathways, have only been shown to have limited effects on tumors with disregulation of other signaling pathways.<br /><br />CU-906 exhibits anti-proliferation activity against a broad range of cancer cell types in in vitro studies, including cell lines that are insensitive to PI3K inhibitors. CU-906's anti-proliferation activity is up to 100 times more potent than that of two leading PI3K inhibitors in development. Efficacy studies in various K-RAS mutant tumor xenograft models indicate that this compound has more potent antitumor activity than a leading PI3K inhibitor that is currently in clinical development, at doses causing no obvious side effects to the tumor-bearing animals.<br /><br />Importantly, CU-906 displays high exposure and long half-life in tumor tissue after IV administration and is orally bioavailable in preclinical models. CU-906 has a half-life of more than 10 hours in xenograft tumors, induces apoptosis and inhibits cell proliferation up to 48 hours following a single dose of the compound to tumor-bearing animals. <b>Statistics</b> : 1 Topics || 2 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> CU-906 (Inhibitor HDAC and PI3K/mTOR) - Channel list - News http://www.pathway2curis.com/cu-906-inhibitor-hdac-and-pi3k-mtor-f17.html http://www.pathway2curis.com/cu-201-an-inhibitor-of-hdac-sfk-and-abl-kinases-f16.html Mon, 06 Dec 2010 18:20:40 GMT CU-201 is a network-targeted molecule that is designed to simultaneously inhibit HDAC, Abl and Src family kinases, the combination of which Curis scientists believe have synergistic interaction against cancer cells. Src family kinases are critical components of multiple signaling pathways that regulate cancer cell proliferation, survival, angiogenesis and metastasis. Thus, as a network disrupting agent that directly targets multiple nodes of genetic and epigenetic dysregulation, CU-201 is expected to impact processes as diverse as proliferation, survival, metastasis and angiogenesis in cancer. In vitro studies demonstrate that CU-201 is able to potently inhibit class I and class II HDACs, Src and Bcr-Abl. It has been shown to outperform single target agents in proliferation assays of hematologic and solid tumor lines and to inhibit migration and invasion of cancer cell lines in vitro. In vivo, it displays potent anti-tumor activity in a variety of hematologic and solid tumor models, including subcutaneous, metastatic and orthotopic models. <b>Statistics</b> : 1 Topics || 1 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases) - Channel list - News http://www.pathway2curis.com/cu-201-an-inhibitor-of-hdac-sfk-and-abl-kinases-f16.html http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-f12.html Sun, 14 Mar 2010 03:20:07 GMT Hedgehog Pathway Clinical Implications <br />Agonist (hair &amp; neuronal) / Antagonist (cancers) / Embryonic Stem Cells <b>Statistics</b> : 3 Topics || 7 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> Hedgehog Pathway Clinical Implications - Channel list - News http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-f12.html http://www.pathway2curis.com/cudc-101-hdac-egfr-her2-inhibitor-f5.html Sun, 28 Feb 2010 00:12:19 GMT Topics surrounding a novel approach to fighting cancers <b>Statistics</b> : 2 Topics || 2 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> CUDC-101 (HDAC/EGFR/Her2 inhibitor) - Channel list - News http://www.pathway2curis.com/cudc-101-hdac-egfr-her2-inhibitor-f5.html http://www.pathway2curis.com/hsp90-debio-0932-cudc-305-f9.html Fri, 19 Feb 2010 22:27:09 GMT Debio 0932 (formerly CUDC-305) is a small molecule inhibitor of Heat Shock Protein 90 (Hsp90). Debio0932 is expected to enter Phase I clinical testing in early Q1 2010. <b>Statistics</b> : 2 Topics || 3 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> HSP90 Debio-0932 (CUDC-305) - Channel list - News http://www.pathway2curis.com/hsp90-debio-0932-cudc-305-f9.html http://www.pathway2curis.com/hedgehog-pathway-diagrams-and-animations-f13.html Sun, 14 Feb 2010 21:59:04 GMT <b>Statistics</b> : 1 Topics || 1 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> Hedgehog Pathway Diagrams and Animations - Channel list - News http://www.pathway2curis.com/hedgehog-pathway-diagrams-and-animations-f13.html http://www.pathway2curis.com/hedgehog-pathway-cancer-and-metastasis-f11.html Fri, 12 Feb 2010 16:40:35 GMT Topics and information of how the Hedgehog pathway tells cells to get up and move (Metastasis) <b>Statistics</b> : 1 Topics || 1 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> Hedgehog Pathway Cancer and Metastasis - Channel list - News http://www.pathway2curis.com/hedgehog-pathway-cancer-and-metastasis-f11.html http://www.pathway2curis.com/hedgehog-pathway-related-cancers-f6.html Mon, 08 Feb 2010 16:46:43 GMT List of Hedgehog Pathway Related Cancers <b>Statistics</b> : 1 Topics || 1 Posts Last post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> Hedgehog Pathway Related Cancers - Channel list - News http://www.pathway2curis.com/hedgehog-pathway-related-cancers-f6.html