Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors - News

Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors - News - Digest http://www.pathway2curis.com/ Novel Anti-Cancer therapies Wed, 08 Sep 2010 23:47:07 GMT Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors - News - Digest http://www.pathway2curis.com/gym_sitemaps/images/rss_forum_big.gif http://www.pathway2curis.com/ http://blogs.law.harvard.edu/tech/rss Google Yahoo MSN Sitemaps and RSS 2.0.0 - © 2006, 2007, 2008 www.phpBB-SEO.com 6 RSS 2.0 feed link : Curis Hedgehog and Beyond --plus multi-targeting cancer inhibitors - News - Digest Novel Anti-Cancer therapies RSS 2.0 feed link http://www.pathway2curis.com/rss/news/digest/rss.xml gym_sitemaps Pancreatic Cancer PII w/ GDC-0449, Gemcitabine, Abraxane http://www.pathway2curis.com/pancreatic-cancer-pii-w-gdc-0449-gemcitabine-abraxane-t22.html Thu, 18 Mar 2010 15:05:15 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> Pancreatic Cancer PII w/ GDC-0449, Gemcitabine, Abraxane The emergence of new small molecules with capacity of blocking the Hedgehog signaling pathway provides a novel therapeutic approach in pancreatic adenocarcinoma treating the primary tumor, stroma, systemic metastases and pancreatic cancer stem cells by hedgehog pathway inhibition. This phase 2 clinical trial ... <a href="http://www.pathway2curis.com/pancreatic-cancer-pii-w-gdc-0449-gemcitabine-abraxane-t22.html">more ...</a> Statistics : 1 Post || 230 Views Post by hedgehog hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/pancreatic-cancer-pii-w-gdc-0449-gemcitabine-abraxane-t22.html Resistance to hedgehog pathway SMO Inhibitors http://www.pathway2curis.com/resistance-to-hedgehog-pathway-smo-inhibitors-t21.html Sun, 14 Mar 2010 03:20:07 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-f12.html" title="Hedgehog Pathway Clinical Implications">Hedgehog Pathway Clinical Implications</a></h5> Resistance to hedgehog pathway SMO Inhibitors Like other cancer drugs there is a growing body of evidence that Cancers can adapt to single mono-therapy of Hedgehog SMO inhibitors <ul><li>Mutation in SMO (the protein that the first generation of Hh inhibitors work on)</li><li>Increased amplification of downstream targets in the ...</li></ul> <a href="http://www.pathway2curis.com/resistance-to-hedgehog-pathway-smo-inhibitors-t21.html">more ...</a> Statistics : 1 Post || 306 Views Post by hedgehog hedgehog Hedgehog Pathway Clinical Implications - News - Digest http://www.pathway2curis.com/resistance-to-hedgehog-pathway-smo-inhibitors-t21.html CUDC-101 Medicinal Chemistry Information http://www.pathway2curis.com/cudc-101-medicinal-chemistry-information-t20.html Sun, 28 Feb 2010 00:12:19 GMT <h5><a href="http://www.pathway2curis.com/cudc-101-hdac-egfr-her2-inhibitor-f5.html" title="CUDC-101 (HDAC/EGFR/Her2 inhibitor)">CUDC-101 (HDAC/EGFR/Her2 inhibitor)</a></h5> CUDC-101 Medicinal Chemistry Information Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer. <img src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/production/jmcmar/0/jmcmar.ahead-of-print/jm901453q/images/medium/jm-2009-01453q_0015.gif" alt="Image" /> <a class="postlink" href="http://pubs.acs.org/doi/full/10.1021/jm901453q">http://pubs.acs.org/doi/full/10.1021/jm901453q</a> By incorporating histone deacetylase (HDAC) inhibitory functionality into the pharmacophore of the epidermal growth factor receptor (EGFR) and human epidermal ... <a href="http://www.pathway2curis.com/cudc-101-medicinal-chemistry-information-t20.html">more ...</a> Statistics : 1 Post || 150 Views Post by hedgehog hedgehog CUDC-101 (HDAC/EGFR/Her2 inhibitor) - News - Digest http://www.pathway2curis.com/cudc-101-medicinal-chemistry-information-t20.html Feb-2010 Hedgehog Pathway Articles http://www.pathway2curis.com/feb-2010-hedgehog-pathway-articles-t19.html Sat, 27 Feb 2010 19:53:38 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-articles-f15.html" title="Hedgehog Pathway Articles">Hedgehog Pathway Articles</a></h5> Feb-2010 Hedgehog Pathway Articles Human Invasive Prostate Cancer Cells <ul>Altogether, these observations suggest that EGFR and sonic hedgehog cascades may represent the potential therapeutic targets of great clinical interest to eradicate the total prostate cancer cell mass and improve the current docetaxel-based therapies against locally advanced and invasive prostate cancers, ...</li></ul> <a href="http://www.pathway2curis.com/feb-2010-hedgehog-pathway-articles-t19.html">more ...</a> Statistics : 1 Post || 181 Views Post by hedgehog hedgehog Hedgehog Pathway Articles - News - Digest http://www.pathway2curis.com/feb-2010-hedgehog-pathway-articles-t19.html Notch-Hedge Clinical Trials Developmental Pathway http://www.pathway2curis.com/notch-hedge-clinical-trials-developmental-pathway-t18.html Fri, 19 Feb 2010 19:14:40 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> Notch-Hedge Clinical Trials Developmental Pathway <a class="postlink" href="http://clinicaltrials.gov/ct2/show/NCT01071564">http://clinicaltrials.gov/ct2/show/NCT01071564</a> The Notch like the Hedgehog pathway is very important in stem cell maintenance and repair of cells. This is also a Roche Compound. <a href="http://www.cnb.uam.es/~jlpompa/" class="postlink">http://www.cnb.uam.es/~jlpompa/</a> The second is a blocker of Hh (hedgehog) signaling, GDC-0449, which we are combining ... <a href="http://www.pathway2curis.com/notch-hedge-clinical-trials-developmental-pathway-t18.html">more ...</a> Statistics : 3 Replies || 281 Views Post by hedgehog hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/notch-hedge-clinical-trials-developmental-pathway-t18.html Hedgehog Pathway Images and Videos http://www.pathway2curis.com/hedgehog-pathway-images-and-videos-t17.html Sun, 14 Feb 2010 21:59:04 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-diagrams-and-animations-f13.html" title="Hedgehog Pathway Diagrams and Animations">Hedgehog Pathway Diagrams and Animations</a></h5> Hedgehog Pathway Images and Videos Genentech: <ul><img src="http://www.biooncology.com/bioonc/images/hedgehog-main.jpg" alt="Image" /> <a href="http://www.biooncology.com/bioonc/media/video/hedgehog/hedgehog.wmv" class="postlink">Genentech Hedgehog Pathway Video</a></ul> You Tube: <ul>An award-winning short video clip exploring the Sonic Hedgehog Signaling Pathway for an Embryology - CBNS 169 course. Won the first ever best editing video award for CBNS 169!!! <img src="{SMILIES_PATH}/icon_e_smile.gif" alt=":)" title="Smile" /> ...</li></ul></li></ul> <a href="http://www.pathway2curis.com/hedgehog-pathway-images-and-videos-t17.html">more ...</a> Statistics : 1 Post || 194 Views Post by hedgehog hedgehog Hedgehog Pathway Diagrams and Animations - News - Digest http://www.pathway2curis.com/hedgehog-pathway-images-and-videos-t17.html Adult Cells and the Hedgehog Pathway http://www.pathway2curis.com/adult-cells-and-the-hedgehog-pathway-t16.html Fri, 12 Feb 2010 16:45:47 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-f12.html" title="Hedgehog Pathway Clinical Implications">Hedgehog Pathway Clinical Implications</a></h5> Adult Cells and the Hedgehog Pathway The theory of Adult Stem Cells causing some/most cancers goes like this. There is long-known association between cancer and chronic tissue injury. For example, if you stay out in the sun your are more likely to develop skin cancer. If you smoke you increase ... <a href="http://www.pathway2curis.com/adult-cells-and-the-hedgehog-pathway-t16.html">more ...</a> Statistics : 5 Replies || 140 Views Post by hedgehog hedgehog Hedgehog Pathway Clinical Implications - News - Digest http://www.pathway2curis.com/adult-cells-and-the-hedgehog-pathway-t16.html Hedgehog Pathway Cancer and Metastasis http://www.pathway2curis.com/hedgehog-pathway-cancer-and-metastasis-t15.html Fri, 12 Feb 2010 16:40:35 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancer-and-metastasis-f11.html" title="Hedgehog Pathway Cancer and Metastasis">Hedgehog Pathway Cancer and Metastasis</a></h5> Hedgehog Pathway Cancer and Metastasis Hedgehog Pathway Cancer and Metastasis Increase Hh Pathway Activation leads to Increase Snail protein expression and Decreased E-cadherin & Tight Junctions E-cadherin stretches across the cell membrane and acts as a sort of molecular “glue” that binds neighboring cells together. About 95 percent of human ... <a href="http://www.pathway2curis.com/hedgehog-pathway-cancer-and-metastasis-t15.html">more ...</a> Statistics : 1 Post || 194 Views Post by hedgehog hedgehog Hedgehog Pathway Cancer and Metastasis - News - Digest http://www.pathway2curis.com/hedgehog-pathway-cancer-and-metastasis-t15.html Hedgehog Pathway Clinical Implications http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-t14.html Fri, 12 Feb 2010 16:38:32 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-f12.html" title="Hedgehog Pathway Clinical Implications">Hedgehog Pathway Clinical Implications</a></h5> Hedgehog Pathway Clinical Implications There are three main focuses of research surrounding the Hh pathway that could become relevant in a clinical application 1) Embryonic Stem cells for regenerative medicine (agonist/antagonist) 2) Agonist (turns pathway on)---which encompasses, degenerative diseases, stroke, hair growth in the adult body 3) Antagonist (turns pathway ... <a href="http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-t14.html">more ...</a> Statistics : 1 Post || 220 Views Post by hedgehog hedgehog Hedgehog Pathway Clinical Implications - News - Digest http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-t14.html PII Trial Started of Pancreatic Cancer and GDC-0499 http://www.pathway2curis.com/pii-trial-started-of-pancreatic-cancer-and-gdc-0499-t12.html Fri, 12 Feb 2010 01:26:19 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> PII Trial Started of Pancreatic Cancer and GDC-0499 <a class="postlink" href="http://clinicaltrials.gov/ct2/show/NCT01064622">http://clinicaltrials.gov/ct2/show/NCT01064622</a> Gemcitabine Hydrochloride With or Without GDC-0449 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer Purpose RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor ... <a href="http://www.pathway2curis.com/pii-trial-started-of-pancreatic-cancer-and-gdc-0499-t12.html">more ...</a> Statistics : 1 Post || 209 Views Post by hedgehog hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/pii-trial-started-of-pancreatic-cancer-and-gdc-0499-t12.html CUDC-305 / Debio HSP90 overcomes erlotinib resistance http://www.pathway2curis.com/cudc-305-debio-hsp90-overcomes-erlotinib-resistance-t11.html Fri, 12 Feb 2010 01:16:25 GMT <h5><a href="http://www.pathway2curis.com/hsp90-debio-0932-cudc-305-f9.html" title="HSP90 Debio-0932 (CUDC-305)">HSP90 Debio-0932 (CUDC-305)</a></h5> CUDC-305 / Debio HSP90 overcomes erlotinib resistance Mol Cancer Ther. 2009 Dec;8(12):3296-306. Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer. Bao R, Lai CJ, Wang DG, Qu H, Yin L, Zifcak B, Tao X, Wang J, Atoyan R, Samson M, Forrester J, Xu ... <a href="http://www.pathway2curis.com/cudc-305-debio-hsp90-overcomes-erlotinib-resistance-t11.html">more ...</a> Statistics : 1 Post || 149 Views Post by hedgehog hedgehog HSP90 Debio-0932 (CUDC-305) - News - Digest http://www.pathway2curis.com/cudc-305-debio-hsp90-overcomes-erlotinib-resistance-t11.html About Debio-0932 (CUDC-305) http://www.pathway2curis.com/about-debio-0932-cudc-305-t10.html Fri, 12 Feb 2010 01:12:24 GMT <h5><a href="http://www.pathway2curis.com/hsp90-debio-0932-cudc-305-f9.html" title="HSP90 Debio-0932 (CUDC-305)">HSP90 Debio-0932 (CUDC-305)</a></h5> About Debio-0932 (CUDC-305) CUDC-305 demonstrated high potency in vitro and in vivo across a wide range of cancers. Most notably, Curis scientists observed complete tumor regression following oral administration of CUDC-305 in a mouse xenograft model of acute myelogenous leukemia(AML). Tumor regression has also been observed after treatment of CUDC-305 ... <a href="http://www.pathway2curis.com/about-debio-0932-cudc-305-t10.html">more ...</a> Statistics : 2 Post || 230 Views Post by hedgehog hedgehog HSP90 Debio-0932 (CUDC-305) - News - Digest http://www.pathway2curis.com/about-debio-0932-cudc-305-t10.html Novartis Pharmaceuticals LDE225 hedgehog inihbitor http://www.pathway2curis.com/novartis-pharmaceuticals-lde225-hedgehog-inihbitor-t9.html Tue, 09 Feb 2010 03:05:53 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> Novartis Pharmaceuticals LDE225 hedgehog inihbitor Advanced Solid Tumors <a href="http://clinicaltrials.gov/ct2/show/NCT00880308?term=LDE225" class="postlink">http://clinicaltrials.gov/ct2/show/NCT00880308?term=LDE225</a> PI This first-in-human dose-escalation study is to characterize the safety, tolerability, pharmacokinetics and pharmacodynamics of LDE225 given orally on a daily dosing schedule in patients with advanced solid tumors. Study Start Date: March 2009 Estimated Primary Completion Date: December 2010 Skin ... <a href="http://www.pathway2curis.com/novartis-pharmaceuticals-lde225-hedgehog-inihbitor-t9.html">more ...</a> Statistics : 2 Post || 460 Views Post by hedgehog hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/novartis-pharmaceuticals-lde225-hedgehog-inihbitor-t9.html Infinity Pharmaceuticals hedgehog inhibitor IPI-926 http://www.pathway2curis.com/infinity-pharmaceuticals-hedgehog-inhibitor-ipi-926-t8.html Tue, 09 Feb 2010 02:56:20 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> Infinity Pharmaceuticals hedgehog inhibitor IPI-926 Advanced and/or Metastatic Solid Tumor Malignancies PI <a href="http://clinicaltrials.gov/ct2/show/NCT00761696?term=IPI-926" class="postlink">http://clinicaltrials.gov/ct2/show/NCT00761696?term=IPI-926</a> A Phase 1 Study of IPI-926 in Patients With Advanced and/or Metastatic Solid Tumor Malignancies <a class="postlink" href="http://clinicaltrials.gov/ct2/results?term=IPI-926">http://clinicaltrials.gov/ct2/results?term=IPI-926</a> <a href="http://www.pathway2curis.com/infinity-pharmaceuticals-hedgehog-inhibitor-ipi-926-t8.html">more ...</a> Statistics : 2 Post || 187 Views Post by hedgehog hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/infinity-pharmaceuticals-hedgehog-inhibitor-ipi-926-t8.html Phase II clinical trial update BCC / Colon / Ovarian cancers http://www.pathway2curis.com/phase-ii-clinical-trial-update-bcc-colon-ovarian-cancers-t7.html Tue, 09 Feb 2010 02:49:44 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> Phase II clinical trial update BCC / Colon / Ovarian cancers First Line Colon Cancer <ul>Completed Enrollment Q2 2009 N=199</ul> Advanced Ovarian Cancer <ul>Completed Enrollment Q4 2009 N=104</ul> Advanced BCC <ul>FPI Q1 2009 N=100</ul> <a href="http://www.pathway2curis.com/phase-ii-clinical-trial-update-bcc-colon-ovarian-cancers-t7.html">more ...</a> Statistics : 1 Post || 110 Views Post by hedgehog hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/phase-ii-clinical-trial-update-bcc-colon-ovarian-cancers-t7.html