http://www.pathway2curis.com/ Novel Anti-Cancer therapies Tue, 07 Feb 2012 21:26:13 GMT http://www.pathway2curis.com/gym_sitemaps/images/rss_forum_big.gif http://www.pathway2curis.com/ http://blogs.law.harvard.edu/tech/rss Google Yahoo MSN Sitemaps and RSS 2.0.0 - © 2006, 2007, 2008 www.phpBB-SEO.com 95 Novel Anti-Cancer therapies RSS 2.0 feed link http://www.pathway2curis.com/rss/news/digest/rss.xml gym_sitemaps http://www.pathway2curis.com/ipi-926-vs-gdc-0449-vs-itraconazole-t58.html Fri, 03 Jun 2011 15:32:35 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> <b>IPI-926 vs GDC-0449 vs Itraconazole</b> All of the following compounds work at blocking the activating forms of a Hh signaling protein called <span style="font-weight: bold">&quot;SMO.&quot; </span> IP-926 team took a well known inhibitor and made it work better. GDC-0449 said I know I want to inhibit SMO lets make a brand new ... <a href="http://www.pathway2curis.com/ipi-926-vs-gdc-0449-vs-itraconazole-t58.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 444 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/ipi-926-vs-gdc-0449-vs-itraconazole-t58.html http://www.pathway2curis.com/nevoid-basal-cell-carcinoma-syndrome-lde225-t57.html Fri, 25 Mar 2011 15:31:38 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-articles-f15.html" title="Hedgehog Pathway Articles">Hedgehog Pathway Articles</a></h5> <b>Nevoid Basal Cell Carcinoma Syndrome LDE225</b> Very interesting article and is a very different approach compared to GDC-0449 LDE225 (Hedgehog inhibitor) <ul><li><span style="font-weight: bold">Cream Form</span></li><li><span style="font-weight: bold">CONS: </span> May not take help Odontogenic keratocyst and Plantar Pits in these patients. Will not prevent new BCCs (Unless they take the cream lotion on a ...</li></ul> <a href="http://www.pathway2curis.com/nevoid-basal-cell-carcinoma-syndrome-lde225-t57.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 917 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Articles - News - Digest http://www.pathway2curis.com/nevoid-basal-cell-carcinoma-syndrome-lde225-t57.html http://www.pathway2curis.com/resolution-of-odontogenic-keratocysts-of-the-jaw-in-basal-ce-t56.html Wed, 23 Mar 2011 16:13:54 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-articles-f15.html" title="Hedgehog Pathway Articles">Hedgehog Pathway Articles</a></h5> <b>Resolution of Odontogenic Keratocysts of the Jaw in Basal Ce</b> Abstract BACKGROUND: Odontogenic keratocysts of the jaw are a central feature of basal cell nevus syndrome (BCNS) and arise from the basal cell layer of the surface epithelium. Although they are benign, they tend to be aggressive, with local invasion ... <a href="http://www.pathway2curis.com/resolution-of-odontogenic-keratocysts-of-the-jaw-in-basal-ce-t56.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 262 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Articles - News - Digest http://www.pathway2curis.com/resolution-of-odontogenic-keratocysts-of-the-jaw-in-basal-ce-t56.html http://www.pathway2curis.com/hedgehog-aacr-2011-t55.html Sat, 19 Mar 2011 17:22:07 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-articles-f15.html" title="Hedgehog Pathway Articles">Hedgehog Pathway Articles</a></h5> <b>Hedgehog AACR 2011</b> <span style="font-weight: bold">Abstract Number: LB-1</span> Presentation Title: <span style="font-weight: bold">An investigator-initiated, phase II randomized, double-blind, placebo-controlled trial of GDC-0449 for prevention of BCCs in basal cell nevus syndrome (BCNS) patients</span> Presentation Time: Sunday, Apr 03, 2011, 10:30 AM -10:50 AM Location: West Hall D, Orange County Convention Center Author Block: Jean ... <a href="http://www.pathway2curis.com/hedgehog-aacr-2011-t55.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 441 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Articles - News - Digest http://www.pathway2curis.com/hedgehog-aacr-2011-t55.html http://www.pathway2curis.com/stanford-university-itraconazole-bcc-t53.html Sat, 12 Mar 2011 21:10:59 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> <b>Stanford University - Itraconazole - BCC</b> Itraconazole, is an already approved drug as an oral antifungal but it has been show by a research team to also inhibit the Hh pathway. It was also shown to inhibit the pathway differently than the current SMO inhibitors in the clinic. ... <a href="http://www.pathway2curis.com/stanford-university-itraconazole-bcc-t53.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 346 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/stanford-university-itraconazole-bcc-t53.html http://www.pathway2curis.com/vismodegib-basal-cell-nevus-syndrome-t47.html Tue, 08 Feb 2011 03:15:23 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> <b>Vismodegib basal cell nevus syndrome</b> NEW ORLEANS - An oral inhibitor of the hedgehog pathway proved dramatically effective for the treatment and prevention of basal cell carcinomas in patients with basal cell nevus syndrome in a phase II study. Indeed, the randomized double-blind trial was halted early for ethical ... <a href="http://www.pathway2curis.com/vismodegib-basal-cell-nevus-syndrome-t47.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 444 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/vismodegib-basal-cell-nevus-syndrome-t47.html http://www.pathway2curis.com/about-cudc-907-t26.html Tue, 11 Jan 2011 01:45:46 GMT <h5><a href="http://www.pathway2curis.com/cu-907-inhibitor-hdac-and-pi3k-mtor-f18.html" title="CU-907 (Inhibitor HDAC and PI3K/mTOR)">CU-907 (Inhibitor HDAC and PI3K/mTOR)</a></h5> <b>About CUDC-907</b> CUDC-907 is an orally bioavailable, multi-targeted small molecule that is designed to inhibit HDAC and PI3K, the combination of which Curis scientists believe have synergistic interaction against cancer cells. In vitro mechanism of action studies demonstrate that CUDC-907 is able to inhibit Class I PI3K and upregulate molecules ... <a href="http://www.pathway2curis.com/about-cudc-907-t26.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 345 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog CU-907 (Inhibitor HDAC and PI3K/mTOR) - News - Digest http://www.pathway2curis.com/about-cudc-907-t26.html http://www.pathway2curis.com/millennium-pharmaceuticals-hedgehog-inhibitor-tak-441-t25.html Sun, 12 Dec 2010 00:41:26 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> <b>Millennium Pharmaceuticals Hedgehog Inhibitor TAK-441</b> <span style="font-weight: bold">A Study of TAK-441 in Adult Patients With Advanced Nonhematologic Malignancie</span>s P1 <a href="http://clinicaltrials.gov/ct2/show/NCT01204073" class="postlink">http://clinicaltrials.gov/ct2/show/NCT01204073</a> This is the first study in which TAK-441 is administered to humans. The patient population will consist of adults aged 18 or older who have advanced nonhematologic malignancies and for whom standard ... <a href="http://www.pathway2curis.com/millennium-pharmaceuticals-hedgehog-inhibitor-tak-441-t25.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 605 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/millennium-pharmaceuticals-hedgehog-inhibitor-tak-441-t25.html http://www.pathway2curis.com/cu-906-preclinical-information-t24.html Tue, 07 Dec 2010 01:52:09 GMT <h5><a href="http://www.pathway2curis.com/cu-906-inhibitor-hdac-and-pi3k-mtor-f17.html" title="CU-906 (Inhibitor HDAC and PI3K/mTOR)">CU-906 (Inhibitor HDAC and PI3K/mTOR)</a></h5> <b>CU-906 Preclinical information</b> Activation of the PI3K-AKT-mTOR signaling pathway plays a crucial role in cancer development and progression. Recently, the inhibition of this pathway has been extensively investigated as a potential cancer therapy. However, primary or acquired resistance may present a major challenge to the success of inhibitors targeting this ... <a href="http://www.pathway2curis.com/cu-906-preclinical-information-t24.html"><b>more ...</b></a> <b>Statistics</b> : 2 Post || 311 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog CU-906 (Inhibitor HDAC and PI3K/mTOR) - News - Digest http://www.pathway2curis.com/cu-906-preclinical-information-t24.html http://www.pathway2curis.com/cu-201-preclinical-data-t23.html Mon, 06 Dec 2010 18:20:40 GMT <h5><a href="http://www.pathway2curis.com/cu-201-an-inhibitor-of-hdac-sfk-and-abl-kinases-f16.html" title="CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases)">CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases)</a></h5> <b>CU-201 Preclinical Data</b> &quot;Recent Evidence has established Src Family Kindases as a critical component of multipule signaling pathways that regulate proliferation survival, angiogenesis and metastasis..... Synergy between HDAC and Src inhibition has been demonstrated in cancer cell lines. CU-201 is a single small molecule to inhibit HDAC, Src, and BCR-Abl. ... <a href="http://www.pathway2curis.com/cu-201-preclinical-data-t23.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 259 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog CU-201 (an Inhibitor of HDAC, SFK and Abl Kinases) - News - Digest http://www.pathway2curis.com/cu-201-preclinical-data-t23.html http://www.pathway2curis.com/pancreatic-cancer-pii-w-gdc-0449-gemcitabine-abraxane-t22.html Thu, 18 Mar 2010 15:05:15 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> <b>Pancreatic Cancer PII w/ GDC-0449, Gemcitabine, Abraxane</b> The emergence of new small molecules with capacity of blocking the Hedgehog signaling pathway provides a novel therapeutic approach in pancreatic adenocarcinoma treating the primary tumor, stroma, systemic metastases and pancreatic cancer stem cells by hedgehog pathway inhibition. This phase 2 clinical trial ... <a href="http://www.pathway2curis.com/pancreatic-cancer-pii-w-gdc-0449-gemcitabine-abraxane-t22.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 1398 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/pancreatic-cancer-pii-w-gdc-0449-gemcitabine-abraxane-t22.html http://www.pathway2curis.com/resistance-to-hedgehog-pathway-smo-inhibitors-t21.html Sun, 14 Mar 2010 03:20:07 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-clinical-implications-f12.html" title="Hedgehog Pathway Clinical Implications">Hedgehog Pathway Clinical Implications</a></h5> <b>Resistance to hedgehog pathway SMO Inhibitors</b> Like other cancer drugs there is a growing body of evidence that Cancers can adapt to single mono-therapy of Hedgehog SMO inhibitors <ul><li>Mutation in SMO (the protein that the first generation of Hh inhibitors work on)</li><li>Increased amplification of downstream targets in the ...</li></ul> <a href="http://www.pathway2curis.com/resistance-to-hedgehog-pathway-smo-inhibitors-t21.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 2644 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Clinical Implications - News - Digest http://www.pathway2curis.com/resistance-to-hedgehog-pathway-smo-inhibitors-t21.html http://www.pathway2curis.com/cudc-101-medicinal-chemistry-information-t20.html Sun, 28 Feb 2010 00:12:19 GMT <h5><a href="http://www.pathway2curis.com/cudc-101-hdac-egfr-her2-inhibitor-f5.html" title="CUDC-101 (HDAC/EGFR/Her2 inhibitor)">CUDC-101 (HDAC/EGFR/Her2 inhibitor)</a></h5> <b>CUDC-101 Medicinal Chemistry Information</b> Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer. <img src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/production/jmcmar/0/jmcmar.ahead-of-print/jm901453q/images/medium/jm-2009-01453q_0015.gif" alt="Image" /> <a class="postlink" href="http://pubs.acs.org/doi/full/10.1021/jm901453q">http://pubs.acs.org/doi/full/10.1021/jm901453q</a> By incorporating histone deacetylase (HDAC) inhibitory functionality into the pharmacophore of the epidermal growth factor receptor (EGFR) and human epidermal ... <a href="http://www.pathway2curis.com/cudc-101-medicinal-chemistry-information-t20.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 574 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog CUDC-101 (HDAC/EGFR/Her2 inhibitor) - News - Digest http://www.pathway2curis.com/cudc-101-medicinal-chemistry-information-t20.html http://www.pathway2curis.com/feb-2010-hedgehog-pathway-articles-t19.html Sat, 27 Feb 2010 19:53:38 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-articles-f15.html" title="Hedgehog Pathway Articles">Hedgehog Pathway Articles</a></h5> <b>Feb-2010 Hedgehog Pathway Articles</b> <span style="font-weight: bold">Human Invasive Prostate Cancer Cells</span> <ul>Altogether, these observations suggest that EGFR and sonic hedgehog cascades may represent the potential therapeutic targets of great clinical interest to eradicate the total prostate cancer cell mass and improve the current docetaxel-based therapies against locally advanced and invasive prostate cancers, ...</li></ul> <a href="http://www.pathway2curis.com/feb-2010-hedgehog-pathway-articles-t19.html"><b>more ...</b></a> <b>Statistics</b> : 1 Post || 696 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Articles - News - Digest http://www.pathway2curis.com/feb-2010-hedgehog-pathway-articles-t19.html http://www.pathway2curis.com/notch-hedge-clinical-trials-developmental-pathway-t18.html Fri, 19 Feb 2010 19:14:40 GMT <h5><a href="http://www.pathway2curis.com/hedgehog-pathway-cancers-clinical-trials.html" title="Hedgehog Pathway Cancers Clinical Trials">Hedgehog Pathway Cancers Clinical Trials</a></h5> <b>Notch-Hedge Clinical Trials Developmental Pathway</b> <a class="postlink" href="http://clinicaltrials.gov/ct2/show/NCT01071564">http://clinicaltrials.gov/ct2/show/NCT01071564</a> The Notch like the Hedgehog pathway is very important in stem cell maintenance and repair of cells. This is also a Roche Compound. <a href="http://www.cnb.uam.es/~jlpompa/" class="postlink">http://www.cnb.uam.es/~jlpompa/</a> The second is a blocker of Hh (hedgehog) signaling, GDC-0449, which we are combining ... <a href="http://www.pathway2curis.com/notch-hedge-clinical-trials-developmental-pathway-t18.html"><b>more ...</b></a> <b>Statistics</b> : 3 Replies || 926 Views Post by <span style="color: #AA0000;" class="username-coloured">hedgehog</span> hedgehog Hedgehog Pathway Cancers Clinical Trials - News - Digest http://www.pathway2curis.com/notch-hedge-clinical-trials-developmental-pathway-t18.html