Hedgehog Pathway Cancer and Metastasis
Posted: Fri Feb 12, 2010 8:40 amHedgehog Pathway Cancer and Metastasis
Increase Hh Pathway Activation leads to Increase Snail protein expression and Decreased E-cadherin & Tight Junctions
E-cadherin stretches across the cell membrane and acts as a sort of molecular “glue” that binds neighboring cells together. About 95 percent of human cancers arise from epithelial cell types that rely on E-cadherin adhesion to maintain their orderly structure. Without this E-cadherin glue, cancer cells are able to metastasize. “Our view is that when a cell metastasizes, something is probably wrong with the cadherin system,” Reynolds said. “When E-cadherin is lost or inactivated, that represents the turning point for metastasis.” Researchers have discovered that E-cadherin is more than just glue holding cells together. (http://www.mc.vanderbilt.edu/reporter/i ... ml?ID=1254)
Snail, a transcriptional repressor of E-cadherin expression, is involved in epithelial-mesenchymal transitions during development. tight junction proteins, including claudin-1, occludin and ZO-1.
http://jcs.biologists.org/cgi/content/full/117/9/1675
Ref
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
Oncogene. 2006 Jan 26;25(4):609-21.
Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
Nature. 2004 Oct 7;431(7009):707-12. Epub 2004 Sep 12.
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Cancer Res. 2007 Mar 1;67(5):2187-96.
Increase Hh Pathway Activation leads to Increase Snail protein expression and Decreased E-cadherin & Tight Junctions
E-cadherin stretches across the cell membrane and acts as a sort of molecular “glue” that binds neighboring cells together. About 95 percent of human cancers arise from epithelial cell types that rely on E-cadherin adhesion to maintain their orderly structure. Without this E-cadherin glue, cancer cells are able to metastasize. “Our view is that when a cell metastasizes, something is probably wrong with the cadherin system,” Reynolds said. “When E-cadherin is lost or inactivated, that represents the turning point for metastasis.” Researchers have discovered that E-cadherin is more than just glue holding cells together. (http://www.mc.vanderbilt.edu/reporter/i ... ml?ID=1254)
Snail, a transcriptional repressor of E-cadherin expression, is involved in epithelial-mesenchymal transitions during development. tight junction proteins, including claudin-1, occludin and ZO-1.
http://jcs.biologists.org/cgi/content/full/117/9/1675
Ref
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
Oncogene. 2006 Jan 26;25(4):609-21.
Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
Nature. 2004 Oct 7;431(7009):707-12. Epub 2004 Sep 12.
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Cancer Res. 2007 Mar 1;67(5):2187-96.